Glioblastoma Multiforme Challenges and Advancements in Treatment

Abstract

Glioblastoma multiforme (GBM) is a tumor that is initiated in glial cells, usually astrocytes. GBM presents difficulties in treatment due to the delocalization of tumor cells, inherent resistance to most cancer drugs, and the limited capacity of the brain to repair itself. Although most cancers have demonstrated an increase in treatment efficacy associated with recent technologies, the recovery rate of GBM has remained stagnant over the years. Recent research, focusing on the immune response of the brain, has sparked hope for better treatments. This paper discusses why previous treatments have been ineffective and describes the recent advancements in treatment.